A gold color metal and enamel device 1 3/16 inches (3.02 cm) in width overall, consisting of a red Greek cross bearing at its center a blue disk with three white stars and surmounting and extending from its upper and horizontal extremities three maroon fleurs-de-lis in front of and extending over a white voided octagon all above a blue scroll inscribed "SCIENCE AND SERVICE" in gold letters.
Maroon and white are colors traditionally associated with the Medical Corps. The cross, a symbol of aid and assistance, and the white octagon, a symbol of life and regeneration, refer to the basic mission of the hospital. The blue disk, with the three white stars taken from the State flag of Tennessee, alludes to the home area of the hospital. The three fleurs-de-lis represent the combined service and battle honors earned in Europe, France and the Rhineland, during World War I and World War II. The color scarlet refers to the Meritorious Unit Citation awarded the parent organization during the Rhineland campaign.
The distinctive unit insignia was originally approved for the 330th General Hospital on 10 July 1970. It was redesignated effective 17 September 1992, with the description and symbolism revised, for the 330th Combat Support Hospital.